Jarrow FORMULAS pharmaceutical grade; stabilized SAM-e 400 provides a full 400 mg SAM-e (net yield) from 800 mg of SAM-e tosylate disulfate. SAM-e 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product. Contains More of the Active S;S Form Found in all living cells; SAM-e is a metabolite of methionine (an essential amino acid). SAM-e is a chiral molecule and consists of two forms: (S;S) SAM-e and (R;S) SAM-e. The biologically active form is the (S;S) structure; while the (R;S) structure is biologically inactive. Jarrow FORMULAS SAM-e is made naturally by microbiological fermentation and then specially processed without solvents to preserve 68-80% (S;S) SAM-e; the highest active level available. SAM-e has been clinically shown to have the following benefits: Joint Strength SAM-e supports the production of healthy connective tissue through transulfuration. In this process; critical components of connective tissue; including glucosamine and the chondroitin sulfates; are sulfated by SAM-e metabolites.* Brain Metabolism SAM-e methylation reactions are involved in the synthesis of neurotransmitters such as L-DOPA; dopamine and related hormones; serotonin; epinephrine and phosphatidylcholine (a component of lecithin).* Longevity Methylation of DNA appears to be important in the suppression of errors in DNA replication. Demethylation of DNA is considered a contributor to the aging process. Proper methylation through substances such as SAM-e positively influences longevity.* Liver SAM-e metabolism supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase and glutathione-S-transferase); which are substances important for liver function.* PRODUCT OF ITALY Keep out of the reach of children.