5-HTP, also known as 5-hydroxytryptophan, is the direct precursor to the neurotransmitter serotonin. Low levels of serotonin are associated with sleep problems, depression, anxiety, compulsive eating disorders, restless leg syndrome, migraines, fibromyalgia and low pain threshold. Many people that are afflicted with one of those conditions often have others, which has led some researchers to label them collectively as 'Low Serotonin Syndrome.'
Serotonin is an important initiator of sleep. In numerous studies 5-HTP has been shown to decrease the time required to get to sleep and to decrease the number of awakening. It also increases REM sleep and deep sleep. By increasing the brain’s concentration of serotonin, an antidepressant effect is created. 5-HTP works by increasing the amount of serotonin manufactured in the brain. Although systematically administered serotonin does not readily enter the brain, its direct precursor, 5-HTP does penetrate the blood-brain barrier, and therefore, dietary consumption of 5-HTP leads to an increase in brain serotonin concentration.
Vitamin B-6 is added as it affects both physical and mental health. It helps with convulsions, headaches, anorexia, depression and numbness, as well as other disorders.
Calcium Citrate is added to help against deficiencies which can attribute to insomnia, muscle cramps, nervousness, convulsions and depression.
Magnesium Citrate is added to assist in calcium uptake, as well as combat deficiencies that can attribute to interference with the transmission of nerve and muscle impulses, depression, dizziness, and muscle weakness and twitching.
Hops may help with anxiety, insomnia, nervousness and pain.
Valerian Root acts as a sedative, as well as help with anxiety, fatigue, insomnia, muscle cramps, nervousness, pain and spasms.
James F. Balch, MD & Phyllis A. Balch, CNC 'Prescription for Nutritional Healing', 1997